Most chemical modifications of proteins within cells occur after they are synthesized through a process called translation
To obtain additional restraints for structural model determination of the p53 TAD2 -FOXO4 FH complex, we determined paramagnetic relaxation enhancements (PREs) for a set of 7 complexes containing spin-labeled (SL) samples ( 15 N-labeled FOXO4 FH + S46C-SL p53 TAD2 , 15 N-labeled FOXO4 FH + Q52C-SL p53 TAD2 , 15 N-labeled p53 TAD2 + Q112C-SL FOXO4 FH , 15 N-labeled p53 TAD2 + D140C-SL FOXO4 FH , 15 N-labeled p53 TAD2 + N145C-SL FOXO4 FH , 15 N-labeled p53 TAD2 + S159C-SL FOXO4 FH , 15 N-labeled p53 TAD2 + S162C-SL FOXO4 FH )
10.1186/s13054-020-03351-1 127 LuoR.YaoY.ChenZ.SunX
For example, Bifidobacterium promote the proliferation of beneficial commensals and inhibit the growth of pathogenic bacteria, thereby improving intestinal barrier function and nutrient absorption efficiency (Li et al., 2025)
Recent insights into the molecular mechanisms underlying pyroptosis and gasdermin family functions
